منابع مشابه
IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain
IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and transforming growth factor-β). In this study we investigated IL-21 and IL-21 receptor (IL-21R) ex...
متن کاملIL 21 R ( interleukin 21 receptor )
The IL21R gene is comprised of 9 exons (+2 alternative first exons), spanning 48.4kb on chromosome 16p11 (Parrish-Novak, 2000). The human IL21R promoter region, contained within nucleotides -789 to +195 (relative to the start of exon 1a) induces the high levels of transcription in reporter assays (Ueda, 2002). A critical SP1 binding site is contained in the region from -80 to -20 and is essenti...
متن کاملIL-21/IL-21R in Autoimmune Diseases
Interleukin-21 (IL-21), the member of the γ-chain-related cytokine family, and its receptor (IL-21R), has been evidenced involving in the immune response, resulting in the development of autoimmune diseases, infectious diseases and tumors. This short communication reviews an overall outline of its genetic variants and expression in autoimmune diseases. It focuses on a series of recent studies t...
متن کاملO17: Inflammation in Brain and Spinal Cord
our goal in this paper is to describe and compare basic immunopathologic pattern of common demyelinating disorder, that is very important to choose the best treatment. The most common disorders are multiple sclerosis, neuromyelitis optica,Anti MOG associated disease,ADEM and autoimmune encephalitis. ADEM consists of ‘‘sleeves’’ of demyelination centered on small, engorge...
متن کاملO 27: Traumatic Brain Injury and Inflammation
Traumatic brain injury (TBI) is a significant public health concern in our country, because of placing in top three most common causes of death and substantial direct and indirect costs to society. The incidence of TBI in our country is 1.7 times of international incidence. Traumatic brain injury induced by primary and secondary mechanisms that give rise to death and neurologic morbidity in pat...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2014
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri3656